![]() Nevertheless, it is highly desirable that the drug transporter molecule must be non-immunogenic, non-toxic, have places for attachment of diagnostic or remedial agents, be electronically or spectroscopically accessible, as well as not exhibit long-term in vivo piling in vital organs. This is so since the drugs can be bound in their inner hollow area, whereas other molecules can be fabricated to the peripheral face to render them biocompatible while targeting the site ( Martincic and Tobias, 2015). While CNTs are used as drug delivery carriers, the nanotube aids in encapsulating drugs in its hollow tube-like structure. Besides other nanomaterials, CNTs have been widely used in pharmaceutical and biomedical applications such as task-specific drug transport, cancer therapy and diagnosis, imaging, and or tissue engineering. Recently, CNT based drug delivery has spawned great interest in medicine delivery and therapeutics, where significant modification of CNT helped in vaccine delivery systems ( Bianco and Prato, 2003) as well as protein transporters ( Kam et al., 2005) apart from being drug nano-carriers. Carbon-based nanostructures are becoming increasingly relevant in the field of neuroscience owing to their many exclusive chemical and physical properties. These nanostructures in almost single dimension are delivering way out to several challenges in delivering drugs to the brain, crossing the tight barrier. ![]() Keyword: Carbon nanotube brain-diseases functionalization blood–brain barrier toxicityĭelivering drugs to the brain remained a challenge until recently when carbon nanotube (CNT) came up with a modification on the surface. This review discussed in detail the advancement achieved so far in delivering drug molecules to the brain using CNT as the carrier and related management of toxicity so that a safer dose delivery can be made. ![]() Surface functionalized CNTs can render themselves efficient as drug carriers to the neurons, for extreme conditions like Alzheimer’s disease, glioblastoma, Parkinson’s disorder, brain stroke, brain tumor, etc. As a result, administering drug molecules of choice to the brain under disease condition become constrained. The human brain restricts movements and or entry of ions, molecules, and cells between the blood and the brain because of the presence of the blood–brain barrier. ![]() Typical intrinsic properties of carbon nanotube (CNTs) like one-dimensional structure with very high mechanical strength, high thermal and electrical conductivity, high aspect ratio, high surface area, ability to conjugate with functional groups, and elevated surface functionalizing capacity have made it a nanostructure of choice to be manipulated for drug delivery for the past two decades. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |